Comparative Studies of the Chromosomal Arrangement in the C-Metaphase Between Normal Karyotype and Trisomy-21
Human chromosomes in amnion cells and lymphocytes with normal karyotype and in lymphocytes with pathological karyotype (2n=47, +21) were compared as to their position in the metaphase.None of the collectives showed sex differences.Measurement of the radial distances revealed more peripheral position of the majority of large chromosomes.The satellit